SML0069

NSC 33994

≥98% (HPLC)

• Synonym(e): (E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6
• Empirische Formel (Hill-System): C₂₈H₄₂N₂O₂
• CAS-Nummer: 82058-16-0
• Molekulargewicht: 438.65
• MDL-Nummer: MFCD20488055
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825133
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥25 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2
• InChI: 1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
• InChIKey: QFNJFVBKASKGEU-OCEACIFDSA-N

Beschreibung

Anwendung

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Biochem./physiol. Wirkung

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.

Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable