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SML0060

Sigma-Aldrich

NB001

≥98% (HPLC)

Synonym(e):

5-[[2-(6-Amino-9H-purin-9-yl)ethyl]amino]-1-pentanol; HTS 09836

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About This Item

Empirische Formel (Hill-System):
C12H20N6O
CAS-Nummer:
686301-48-4
Molekulargewicht:
264.33
MDL-Nummer:
MFCD03086724
UNSPSC-Code:
41106305
PubChem Substanz-ID:
329825126
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to tan

Löslichkeit

H2O: ≥24 mg/mL

Lagertemp.

−20°C

SMILES String

Nc1ncnc2n(CCNCCCCCO)cnc12

InChI

1S/C12H20N6O/c13-11-10-12(16-8-15-11)18(9-17-10)6-5-14-4-2-1-3-7-19/h8-9,14,19H,1-7H2,(H2,13,15,16)

InChIKey

CVPTTZZCRDVGSU-UHFFFAOYSA-N

Anwendung

NB001 may be used in adenylyl cyclase 1-mediated cell signaling studies.

Biochem./physiol. Wirkung

NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. NB001 may reduce cAMP accumulation in cells through an unknown mechanism that is dependent on AC1.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
061M4720V

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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 397-405 (2017-07-15)
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and
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