SML0002

C646

≥98% (HPLC)

• Synonym(e): 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
• Empirische Formel (Hill-System): C₂₄H₁₉N₃O₆
• CAS-Nummer: 328968-36-1
• Molekulargewicht: 445.42
• MDL-Nummer: MFCD01784780
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825079
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: red to brown
• Löslichkeit: DMSO: >25 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O
• InChI: 1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
• InChIKey: HEKJYZZSCQBJGB-UNOMPAQXSA-N

Beschreibung

Anwendung

C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.

Biochem./physiol. Wirkung

C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.

C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.

C646 is a potent, competitive, and selective histone acetyltransferase (HAT) p300/CBP inhibitor.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable