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Key Documents

SCP0135

Sigma-Aldrich

Endothelin β Receptor Agonist IRL 1620

Synonym(e):

Endothelin Agonist, Endothelin Receptor Agonist

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About This Item

Empirische Formel (Hill-System):
C86H116N17O27
Molekulargewicht:
1819.94
UNSPSC-Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

Form

lyophilized

Zusammensetzung

Peptide Content, ≥80%

Lagerbedingungen

protect from light

Löslichkeit

1 mg/mL at in water (Add acetonitrile dropwise to solution in water, mixing until the peptide dissolves)

Lagertemp.

−20°C

Amino Acid Sequence

Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

Anwendung

IRL-1620 is used as a specific endothelin-B receptor (ET(B)-R) agonist.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H300 + H330

Gefahreneinstufungen

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Manish S Lavhale et al.
Pharmacological research, 62(6), 489-499 (2010-09-10)
Clonidine decreases mean arterial pressure (MAP) by acting as an α(2)-adrenergic receptor (AR) agonist in the central nervous system; it also acts on peripheral α-ARs to produce vasoconstriction. Endothelin (ET) has been shown to modulate the action of ARs. The
Fernando S Carneiro et al.
The journal of sexual medicine, 5(12), 2793-2807 (2008-10-01)
The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation
A Gulati et al.
Arzneimittel-Forschung, 62(1), 14-17 (2012-02-15)
ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor
Mary G Leonard et al.
Brain research, 1420, 48-58 (2011-10-01)
Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies indicate that ET(B) receptors may provide both vasodilatation and neuroprotection. The purpose of this study was to determine the effect of selectively

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