SAB4503898

Anti-phospho-Aurora Kinase (pThr²⁸⁸) antibody produced in rabbit

affinity isolated antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 45 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:1000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: O14965
• UniProt-Hinterlegungsnummer: O14965
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pThr288)
• Angaben zum Gen: human ... AURKA(6790)

Beschreibung

Allgemeine Beschreibung

Aurora kinase A (AURKA) belongs to the serine/threonine kinase family. It is localized to centrosomes. AURKA gene is located on human chromosome 20q13.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human Aurora Kinase around the phosphorylation site of Thr288.

Immunogen Range: 256-305

Anwendung

Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit has been used in immunofluorescence staining.

Biochem./physiol. Wirkung

Aurora kinase A (AURKA) is involved in maintaining the stability of mitosis and chromosomes. During mitosis, AURKA participates in centrosome maturation control, mitotic entry, bipolar spindle formation, and segregation. AURKA also participates in chromosome alignment and cytokinesis. It controls several oncogenic signaling pathways. AURKA plays a major role in the self-renewal, reprogramming, and differentiation of stem cells. Knockdown of AURKA gene affects the maturation of the centrosome. Abnormality in the AURKA gene leads to aberrant cell division and aneuploidy, which in turn affects the stability of the genome and contributes to carcinogenesis. Overexpression of the AURKA gene is seen in gastrointestinal, pancreatic, and liver cancers. It can act as a candidate gene to predict colorectal adenocarcinoma.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable