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Merck

SAB4503363

Sigma-Aldrich

Anti-ACSS1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, Acetyl-coenzyme A synthetase 2-like, Acyl-CoA synthetase short-chain family member 1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 74 kDa

Speziesreaktivität

human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ACSS1(84532)

Allgemeine Beschreibung

Anti-ACSS1 Antibody detects endogenous levels of total ACSS1 protein.
Acetyl coenzyme A (CoA) synthetase 1 (ACSS1) is an enzyme which is also termed as Acecs2. It is present in the mitochondria. It is located on human chromosome 20p11.21.

Immunogen

The antiserum was produced against synthesized peptide derived from human ACSS1.

Immunogen Range: 611-660

Biochem./physiol. Wirkung

Acetyl coenzyme A (CoA) synthetase 1 (ACSS1) participates in the oxidation of acetate. It converts acetate to acetyl-CoA in an ATP-dependent reaction. ACSS1 promotes aggressive tumor growth.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.
Lakhter AJ, et al.
The Journal of Biological Chemistry, 291(42), 21869-21879 (2016)
Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer.
Kawaguchi K, et al.
The American Journal of Pathology, 186(8), 2055-2067 (2016)
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.
Fujino T, et al.
The Journal of Biological Chemistry, 276(14), 11420-11426 (2001)
Bjoern Schwer et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(27), 10224-10229 (2006-06-22)
We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matrix protein. AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and

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