Direkt zum Inhalt
Merck

SAB4502011

Sigma-Aldrich

Anti-INOS antibody produced in rabbit

affinity isolated antibody

Synonym(e):

HEP-NOS, hepatocyte NOS, inducible, inducible NOS, nitric oxide synthase

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 131 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... NOS2(4843)

Verwandte Kategorien

Allgemeine Beschreibung

Anti-INOS antibody detects endogenous levels of total INOS protein.
The INOS (inducible nitric oxide synthase) gene is mapped to human chromosome 17q11.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human iNOS.

Immunogen Range: 117-166

Anwendung

Anti-INOS, N-Terminal antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem./physiol. Wirkung

Upregulation of INOS (inducible nitric oxide synthase) is observed during infections, tissue injury, and inflammation. INOS is responsible to produce NO (nitric oxide), which controls blood flow by inducing vascular relaxation. NO acts as a neurotransmitter and can facilitate immune responses. NO can also bring about anti-thrombotic and anti-inflammatory effects in response to oxidative stress, hypoxia, inflammatory cytokines (TNF-α, IL-1β, IFN-γ), and lipopolysaccharide endotoxin. iNOS generates more NO than the neuronal and endothelial NOS. Unlike the two isoforms, iNOS is calcium independent. INOS might be associated with type 2 diabetes mellitus.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Yan Yang et al.
Molecular medicine reports, 13(2), 1220-1226 (2015-12-10)
Spinal nitric oxide is involved in the mechanisms of pain generation and transmission during inflammatory and neuropathic pain. The aim of the present study was to explore the role of spinal nitric oxide in the development of bone cancer pain.
Feng Chen et al.
IUBMB life, 68(7), 516-525 (2016-05-20)
Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3) gene play important roles in the susceptibility to type 2 diabetes mellitus (T2DM). The present study aims to detect the potential association of NOS2 and NOS3 gene polymorphisms with
R A Lea et al.
American journal of medical genetics, 105(1), 110-113 (2001-06-27)
Migraine is a debilitating disorder affecting approximately 12% of Caucasian populations. The disease has a large genetic component, although at present the type and number of genes involved is unclear. Candidate gene studies may be useful strategies for identifying genes
Mateusz Adamiak et al.
Stem cell reviews, 13(1), 92-103 (2016-10-19)
Nitric oxide (NO) is a gaseous free radical molecule involved in several biological processes related to inflammation, tissue damage, and infections. Based on reports that NO inhibits migration of granulocytes and monocytes, we became interested in the role of inducible
Xingfang Yu et al.
Food & function, 11(6), 5513-5524 (2020-06-10)
Obesity is related to osteoarthritis (OA). Aberrant lipid metabolism results in increased levels of free fatty acids, such as palmitate (PA), leading to inflammatory responses and excess catabolism of chondrocytes. Asiatic acid (AA), a plant anti-inflammatory compound, has been reported

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.