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Key Documents

SAB4501477

Sigma-Aldrich

Anti-5-HT-2C antibody produced in rabbit

affinity isolated antibody

Synonym(e):

5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 2C, Serotonin receptor 2C

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 51 kDa

Speziesreaktivität

human, rat, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI-Hinterlegungsnummer

P28335

UniProt-Hinterlegungsnummer

P28335

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... HTR2C(3358)

Verwandte Kategorien

Allgemeine Beschreibung

5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) receptor is a seven transmembrane domain protein. It is located on human chromosome Xq22-23.
Anti-5-HT-2C antibody detects endogenous levels of total 5-HT-2C protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human 5-HT-2C.

Immunogen Range: 161-210

Biochem./physiol. Wirkung

In the nervous system, 5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) participates in coordinating the intracellular responses to serotonin. It plays a major role in the modulation of energy homeostasis.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Xu Y, et al.
Neuron, 60(4), 582-589 (2008)
Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows
Quilter CR, et al.
BMC Neuroscience (2012)
Rajat K Das et al.
Respiratory physiology & neurobiology, 260, 105-113 (2018-11-18)
Hypoglossal (XII) motoneurons are activated by type 2 receptors for serotonin (5-HT). This activation is especially strong during wakefulness which facilitates diverse motor functions of the tongue, including the maintenance of upper airway patency in obstructive sleep apnea (OSA) patients.
Katsura Nozawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3408-3413 (2009-02-13)
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and extrinsic nerves, which results in various physiological
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of

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