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SAB4500599

Sigma-Aldrich

Anti-CDCA2 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

FLJ25804, MGC129906, MGC129907, cell division cycle associated 2

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 112 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

Q69YH5

UniProt-Hinterlegungsnummer

Q69YH5

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CDCA2(157313)

Allgemeine Beschreibung

Cell division cycle associated 2 (CDCA2) is expressed in the nucleus. The gene encoding it is localized on human chromosome 8p21.2. Anti-CDCA2 Antibody detects endogenous levels of total CDCA2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human CDCA2.

Immunogen Range: 511-560

Biochem./physiol. Wirkung

Cell division cycle associated 2 (CDCA2) dephosphorylates histone H3 and modulates DNA damage responses. It has roles in nuclear envelope reformation and chromatin reorganization. The protein has been shown to be upregulated in neuroblastoma tumors and melanoma cell lines.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Pauline Lagarde et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(5), 608-615 (2013-01-16)
Synovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;18) translocation in SS oncogenesis is well established, the genetic basis of SS metastasis is still poorly
Paola Vagnarelli et al.
Nucleus (Austin, Tex.), 3(2), 138-142 (2012-05-05)
Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner:
Paola Vagnarelli
Advances in experimental medicine and biology, 773, 401-414 (2014-02-25)
Nuclear structure and chromatin changes are very useful biomarkers in cancer diagnosis. Despite this, their biological significance and relevance to cancer progression are still not well understood. The identification of new proteins that link the nuclear envelope to chromatin organization
Fumihiko Uchida et al.
PloS one, 8(2), e56381-e56381 (2013-02-19)
Cell division cycle associated 2 (CDCA2) recruits protein phosphatase 1 to chromatin to antagonize activation of ataxia telangiectasia mutated (ATM)-dependent signal transduction. ATM kinase plays a critical role in the DNA damage response and its phosphorylation cascade to inhibit the

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