SAB4301289

Anti-phospho-BLK (pTyr⁵⁰¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): B lymphocyte kinase, EC 2.7.10.2, Tyrosine-protein kinase BLK, kinase Blk, p55-BLK
• UNSPSC-Code: 12352203
• NACRES: NA.41
• Klon: polyclonal
• application: IHC
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: 1:50-1:100
• citations: 3

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 57 kDa
• Speziesreaktivität: human
• Konzentration: 1.0 mg/mL
• Methode(n): immunohistochemistry: 1:50-1:100
• Isotyp: IgG
• Hinterlegungsnummer: NP_001706.2.
• UniProt-Hinterlegungsnummer: P51451
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr501)
• Angaben zum Gen: human ... BLK(640)

Beschreibung

Allgemeine Beschreibung

B lymphoid tyrosine kinase (BLK) protein belongs to the Src kinase family. It has an Src homology 3 (SH3) and an Src homology 2 (SH2) domain N-terminal to the catalytic kinase domain. The BLK gene is located on human chromosome 8p23.1.

Spezifität

The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK.

Biochem./physiol. Wirkung

B lymphoid tyrosine kinase (BLK) protein has oncogenic properties. It helps B-cell receptors transmit signals and may be important for B-cell repertoire development and mature B-cell activity. BLK participates in B-cell antigen receptor signaling. The BLK gene polymorphisms are linked to renal dysfunction in people with systemic lupus erythematosus.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable