SAB4300221

Anti-phospho-EIF2S1 (pSer⁵¹) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-EIF-2 antibody produced in rabbit, Anti-EIF-2A antibody produced in rabbit, Anti-EIF-2alpha antibody produced in rabbit, Anti-EIF2 antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa antibody produced in rabbit
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~38 kDa
• Speziesreaktivität: rat, mouse, human
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (E-L-SP-R-R)
• NCBI-Hinterlegungsnummer: NP_004085.1
• UniProt-Hinterlegungsnummer: P05198
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer51)
• Angaben zum Gen: human ... EIF2S1(1965)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of serine 51 (E-L-S(p)-R-R), according to the protein EIF2S1.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable