SAB4300140

Anti-phospho-PRKCQ (pSer⁶⁹⁵) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-MGC126514 antibody produced in rabbit, Anti-MGC141919 antibody produced in rabbit, Anti-PRKCT antibody produced in rabbit, Anti-nPKC-theta antibody produced in rabbit, Anti-protein kinase C, theta antibody produced in rabbit
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~80 kDa
• Speziesreaktivität: human
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• Isotyp: IgG
• Immunogene Sequenz: (N-F-SP-F-M)
• NCBI-Hinterlegungsnummer: NP_006248.1
• UniProt-Hinterlegungsnummer: Q04759
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pSer695)
• Angaben zum Gen: human ... PRKCQ(5588)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of serine 695 (N-F-S(p)-F-M), according to the protein PRKCQ.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. Ref.8 PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable