SAB4200039

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-5-hydroxytryptamine transporter, Anti-5HTT, Anti-HTT, Anti-OCD1, Anti-SERT, Anti-SLC6A4 solute carrier family 6, member 4
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~83 kDa
• Speziesreaktivität: human
• Konzentration: ~1.5 mg/mL
• Methode(n): western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates
• UniProt-Hinterlegungsnummer: P31645
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: rat ... Slc6a4(25553)

Beschreibung

Allgemeine Beschreibung

Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.

Anwendung

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

Biochem./physiol. Wirkung

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increases the risk of susceptibility to autism and rigid-compulsive behaviors.

The polymorphic promoter region of the serotonin transporter gene serotonin-transporter-linked polymorphic region (5HTTLPR), has been suggested to affect serotonin uptake and may play a role in the pathogenesis of depression, obsessive-compulsive disorder (OCD) and aggressive behavior.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable