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Merck

SAB4200006

Sigma-Aldrich

Anti-TDP-43 (N-terminal region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-ALS10, Anti-TARDBP, Anti-TARDP43, Anti-Tar DNA binding protein 43

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~43 kDa

Speziesreaktivität

mouse, human

Konzentration

~1.0 mg/mL

Methode(n)

immunohistochemistry: 5-10 μg/mL using human or mouse kidney
indirect immunofluorescence: 5-10 μg/mL using HepG2 cells
western blot: 1.5-3.0 μg/mL using HepG2 cell lysates

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TARDBP(23435)
mouse ... Tardbp(230908)

Allgemeine Beschreibung

TDP-43 (TAR DNA binding protein, TARDP) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is predominantly localized to the nucleus.

Anwendung

Anti-TDP-43 (N-terminal region) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry
  • immunuprecipitation

Biochem./physiol. Wirkung

TDP-43 is also involved in mediating the transcription regulation of human immune deficiency virus (HIV). TDP-43 has been identified as the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites, indicating that redistribution of TDP-43 to the cytoplasm is a pathogenic mechanism. Several pathogenic TDP43 mutations have been identified in familial ALS, causing aberrant cleavage of TDP-43 to C-terminal fragments, and predisposing nuclear TDP-43 to redistribute to the cytoplasm and form pathological aggregates. Abnormal phosphorylation of TDP-43 at Ser409/410 has also been observed in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD-U and ALS) suggesting a toxic gain of function leading to apoptosis.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Schwenk BM, et al.
The Embo Journal, 35(21), 2350-2370 (2016)
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
Zhang YJ, et al.
Proceedings of the National Academy of Sciences of the USA, 106(18), 7607-7612 (2009)
Cross-regulation between TDP-43 and paraspeckles promotes pluripotency-differentiation transition
Modic M, et al.
Molecular Cell (2019)
TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies
Arnold, Stacy J and Dugger, Brittany N and Beach, Thomas G
Acta Neuropathologica, 126(1), 51-57 (2013)
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
Ayala YM, et al.
Proceedings of the National Academy of Sciences of the USA, 105(10), 3785-3789 (2008)

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