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Merck

SAB3501176

Sigma-Aldrich

Anti-CXCR4 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.43

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

liquid

Speziesreaktivität

rat, human, mouse

Konzentration

1 mg/mL

Methode(n)

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CXCR4(7852)

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Allgemeine Beschreibung

CXCR4, a G-protein coupled receptor (GPCR) with seven transmembrane domains, is a CXC chemokine receptor specific for stromal-derived-factor-1 (SDF-1 or CXCL12). CXCR4 was initially discovered as one of the co-receptors for HIV entry into CD4+ T cells. Blocking CXCR4 could be potentially used as novel therapeutics for HIV treatment.CXCR4 signaling plays an important role in the migration, proliferation and quiescence of hematopoietic stem cell and their retention within the bone marrow, where it has high levels of SDF-1/CXCL12. It has been demonstrated that CXCR4 signaling mediates CD20 up-regulation on B cells.CXCR4 is highly expressed in more than 23 types of cancer, including breast cancer, ovarian cancer, melanoma, and prostate cancer, while there is very less or no expression of CXCR4 in healthy tissues. CXCR4 expression in cancer cells has been reported to be associated with tumor survival, growth and metastasis in tissues with high levels of SDF-1/CXCL12, such as lungs, liver and bone marrow (4,5).CXCR4 has been shown to regulate neuronal migration, cell positioning and axon wiring (6,7). CXCR4 mutant mice displayed aberrant neuronal distribution, which implicates the role in neuronal disorders such as epilepsy. CXCR4 is also involved in WHIM syndrome. WHIM mutations in CXCR4 were recently found in patients with Waldenstrom′s macroglobulinemia, and these mutations are correlated to clinical resistance to ibrutinib (9,10).

Immunogen

Anti-CXCR4 antibody was raised against a peptide corresponding to 15 amino acids near the center of human CXCR4 isoform b. The immunogen is located within amino acids 170-220 of CXCR4.

Anwendung

Antibody validated: Western Blot in human, mouse, and rat samples; Immunohistochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

Physikalische Form

Supplied in PBS containing 0.02% sodium azide.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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