SAB1402151

Monoclonal Anti-COL1A1 antibody produced in mouse

clone 3G3, purified immunoglobulin, buffered aqueous solution

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 3G3, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~35.79 kDa
• Speziesreaktivität: human, mouse
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotyp: IgG3κ
• NCBI-Hinterlegungsnummer: NM_000088
• UniProt-Hinterlegungsnummer: P02452
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... COL1A1(1277)

Beschreibung

Allgemeine Beschreibung

The COL1A1 (collagen type I α 1 chain) gene codes for the pro-α1 chains of type I collagen. The triple helix of the type I collagen is composed of two α chains and this protein is localized to connective tissues and predominantly expressed in bone, cornea, dermis and tendon. COL1A1 is mapped to human chromosome 17q21.33. 90% of the bone matrix comprises of collagen type I.

Immunogen

COL1A1 (NP_000079.1, 1021 a.a. ~ 1108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
EGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK

Biochem./physiol. Wirkung

Proteins belonging to the collagen family, supports and nourishes body tissues such as tendons, cartilage, skin, and sclera of the eye. Mutation in COL1A1 (collagen type I α 1 chain) gene is associated with a number of connective tissue disorders such as Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, osteogenesis imperfecta types I-IV, idiopathic osteoporosis and Caffey Disease. The COL1A1 is associated with a particular type of skin tumor called dermatofibrosarcoma protuberans which is due to over expression of growth factors. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable