SAB1300113
Anti-TGFBR1 (center) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(e):
TGF-β receptor type I, TGFR-1, TGF-β type I receptor, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5
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Alle Fotos(3)
About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
IgG fraction of antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Speziesreaktivität
human, mouse
Methode(n)
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... TGFBR1(7046)
Allgemeine Beschreibung
TGFBR1 (transforming growth factor β receptor 1) gene is mapped to human chromosome 9q22.33. TGFBR1 is known to localize in the focal adhesions of the cell surface.
The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
Immunogen
TGFBR1 (NP_004603, 138-173)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.
Anwendung
Anti-TGFBR1 (center) antibody produced in rabbit has been used in western blot.
Biochem./physiol. Wirkung
TGFBR1 (transforming growth factor β receptor 1) stimulates signaling pathway that mediates cell growth and division. The complex formed by TGFBR2 with TGFBR1 results in the phosphorylation and activation of TGFBR1. TGFBR1 is responsible for the activation of canonical Smad (mothers against decapentaplegic homolog 3) proteins and transcriptional factors Snail (zinc finger protein) and Twist (twist family bHLH transcription factor 1). The activation of a number of non-canonical effectors such as RhoA (ras homolog family member A), TAK1 (transforming growth factor-β-activated kinase 1) and Akt (RAC-α serine/threonine-protein kinase) is also associated with TGFBR1. The arrangement of the TGFBR1 receptor along with TGFBR2 at the focal adhesions mediates the multimerization and stimulation of TGFβ ligand. Downregulation of TGFBR1 is observed in breast cancer. TGFBR1 is also known to be associated with colorectal cancer.
Physikalische Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Li Yang et al.
PloS one, 11(5), e0155270-e0155270 (2016-05-14)
Endometrial cancer (EC) is a complex disease involving multiple gene-gene and gene-environment interactions. TGF-β signaling plays pivotal roles in EC development. This study aimed to investigate whether the genetic polymorphisms of TGF-β signaling related genes TGFB1, TGFBR1, SNAI1 and TWIST1
Rosa M Xicola et al.
Carcinogenesis, 37(8), 751-758 (2016-05-29)
The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated
Ibrahim Y Hachim et al.
Human pathology, 57, 140-151 (2016-10-25)
The transforming growth factor-β (TGFβ) plays a dual role in breast cancer, acting as a tumor suppressor in early carcinomas while promoting tumor metastasis in more advanced breast carcinoma. As a result, the prognostic role of TGFβ and its signaling
Joanna P Rys et al.
eLife, 4, e09300-e09300 (2015-12-15)
Cell surface receptors are central to the cell's ability to generate coordinated responses to the multitude of biochemical and physical cues in the microenvironment. However, the mechanisms by which receptors enable this concerted cellular response remain unclear. To investigate the
Sergiy Klid et al.
Stem cell research & therapy, 12(1), 608-608 (2021-12-22)
An environment of gestational diabetes mellitus (GDM) can modify the phenotype of stem cell populations differentially according to their placental localization, which can be useful to study the consequences for the fetus. We sought to explore the effect of intrauterine
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