S8689

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

• Synonym(e): SuperFas Ligand^™
• MDL-Nummer: MFCD01092558
• UNSPSC-Code: 12352202
• NACRES: NA.56

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in HEK 293 cells
• Assay: ≥95% (SDS-GE)
• Form: lyophilized powder
• Mol-Gew.: 32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions); 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
• Methode(n): ligand binding assay: suitable
• UniProt-Hinterlegungsnummer: P48023
• Lagertemp.: −20°C
• Angaben zum Gen: human ... FASLG(356)

Beschreibung

Anwendung

ED₅₀ = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL^™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem./physiol. Wirkung

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Rechtliche Hinweise

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable