S6949

β-Synuclein V70M histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• Synonym(e): SNCB
• MDL-Nummer: MFCD08705537
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in E. coli
• Qualitätsniveau: 200
• Assay: ≥90% (SDS-PAGE)
• Form: lyophilized powder
• UniProt-Hinterlegungsnummer: Q16143
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... SNCB(6620)

Beschreibung

Biochem./physiol. Wirkung

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution.

Rekonstituierung

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)