S0323

Sematilide -monohydrochlorid Monohydrat

≥98% (HPLC), powder

• Synonym(e): CK-1752A, N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide -monohydrochlorid Monohydrat
• Empirische Formel (Hill-System): C₁₄H₂₃N₃O₃S· HCl · H₂O
• CAS-Nummer: 101526-62-9
• Molekulargewicht: 367.89
• MDL-Nummer: MFCD11041004
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824420

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O.Cl.CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1
• InChI: 1S/C14H23N3O3S.ClH.H2O/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20;;/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18);1H;1H2
• InChIKey: HCGUEOOYHHAYIM-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (I_Kr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)