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S009

Sigma-Aldrich

LY-165,163

solid

Synonym(e):

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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About This Item

Empirische Formel (Hill-System):
C19H22F3N3
CAS-Nummer:
1814-64-8
Molekulargewicht:
349.39
MDL-Nummer:
MFCD00055098
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278123
NACRES:
NA.77

Form

solid

Qualitätsniveau

100

Farbe

off-white

Löslichkeit

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES String

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChIKey

GAAKALASJNGQKD-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1A(3350) , HTR1D(3352)

Biochem./physiol. Wirkung

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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R W Fuller et al.
The Journal of pharmacology and experimental therapeutics, 239(2), 454-459 (1986-11-01)
1-(m-Trifluoromethylphenyl)-4-(p-aminophenylethyl)piperazine (LY 156163), reported previously to have selective affinity for the 5-HT1A subtype of serotonin receptor in vitro, was studied at doses of 1.25 to 20 mg/kg i.p. in rats to determine if it had properties characteristic of centrally acting
R B McCall et al.
The Journal of pharmacology and experimental therapeutics, 242(3), 1152-1159 (1987-09-01)
Previous studies indicate that serotonin (5-HT) neurons provide a tonic excitatory input to central sympathetic neurons. The purpose of the present study was to utilize a number of 5-HT agonists in order to provide insights into the general function of
P H Hutson et al.
European journal of pharmacology, 138(2), 215-223 (1987-06-19)
1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY 165163, PAPP) (1 mg/kg s.c.) significantly decreased 5-hydroxytryptophan (5-HTP) accumulation in cortex, hippocampus, striatum, septum, pons + medulla and midbrain and increased DOPA accumulation in the cortex and striatum following inhibition of aromatic amino acid decarboxylase with NSD
M De Vivo et al.
Biochemical pharmacology, 40(7), 1551-1558 (1990-10-01)
5-Hydroxytryptamine (serotonin, 5-HT) stimulates basal adenylyl cyclase activity in membranes from guinea pig or rat hippocampi, but 5-HT inhibits forskolin-stimulated adenylyl cyclase activity in these same membranes. The opposing effects of 5-HT on adenylyl cyclase activity indicate that distinct 5-HT
M L Cohen et al.
Life sciences, 38(1), 1-5 (1986-01-06)
The nature of the receptor mediating serotonin contraction in the rat stomach fundus has not been clearly associated with either 5HT1 or 5HT2 receptors. We have explored the possibility that such receptors in the rat fundus may better correlate with
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