R1033

RN-1747

≥98% (HPLC)

• Synonym(e): 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine;, 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine
• Empirische Formel (Hill-System): C₁₇H₁₈ClN₃O₄S
• CAS-Nummer: 1024448-59-6
• Molekulargewicht: 395.86
• MDL-Nummer: MFCD04154169
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329823995
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: light yellow to light tan
• Löslichkeit: DMSO: ≥10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [O-][N+](=O)c1cc(Cl)ccc1S(=O)(=O)N2CCN(CC2)Cc3ccccc3
• InChI: 1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
• InChIKey: ZNLVYSJQUMALEO-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

TRPV4, a close relative of the vanilloid receptor TRPV1, is activated by diverse modalities such as endogenous lipid ligands, hypotonicity, protein kinases and, possibly, mechanical inputs. TRPV4 is a nociceptor playing an important role in inflammatory and neuropathic mechanical hyperalgesia in rodent models apparently specifically activated under pathological conditions.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable