PZ0193

Axitinib

≥98% (HPLC), powder, tyrosine kinase inhibitor

• Synonym(e): AG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
• Empirische Formel (Hill-System): C₂₂H₁₈N₄OS
• CAS-Nummer: 319460-85-0
• Molekulargewicht: 386.47
• MDL-Nummer: MFCD09837898
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329823767
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Axitinib, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥8 mg/mL
• Lagertemp.: room temp
• SMILES String: CNC(=O)c1ccccc1Sc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2
• InChI: 1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
• InChIKey: RITAVMQDGBJQJZ-FMIVXFBMSA-N
• Angaben zum Gen: human ... FLT1(2321) , FLT4(2324) , KDR(3791)

Beschreibung

Anwendung

Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW).

Biochem./physiol. Wirkung

Axitinib (AG-013736) is an orally available, potent (picomolar) and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. The drug blocks VEGF-mediated endothelial cell survival, tube formation, and downstream signaling through endothelial nitric oxide synthase, Akt and extracellular signal-regulated kinase.

Orally available, potent and selective inhibitor of VEGF receptors 1, 2 and 3

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Rechtliche Hinweise

Sold for research purposes under agreement from Pfizer Inc.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H400
• P-Sätze: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable