P8982

Anti-phospho-p53 (pSer³⁹²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL-Nummer: MFCD02097164
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Mol-Gew.: antigen 53 kDa
• Speziesreaktivität: mouse, human
• Methode(n): microarray: suitable; western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
• UniProt-Hinterlegungsnummer: P04637
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... TP53(7157) ; mouse ... Trp53(22059)

Beschreibung

Allgemeine Beschreibung

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Spezifität

Does not react with non-phosphorylated p53.

Immunogen

synthetic peptide corresponding to residues around Ser³⁹² of human p53 conjugated to KLH.

Biochem./physiol. Wirkung

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Physikalische Form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

Angaben zur Herstellung

Purified using protein A and peptide affinity chromatography.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable