P7791

Prazosin -hydrochlorid

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Synonym(e): 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2-furanylcarbonyl)-piperazin -hydrochlorid, Furazosin -hydrochlorid
• Empirische Formel (Hill-System): C₁₉H₂₁N₅O₄ · HCl
• CAS-Nummer: 19237-84-4
• Molekulargewicht: 419.86
• Beilstein: 4303561
• EG-Nummer: 242-903-4
• MDL-Nummer: MFCD00058177
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277793
• NACRES: NA.77

Eigenschaften

• product name: Prazosin -hydrochlorid, ≥99.0% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥99.0% (HPLC)
• Form: powder
• Löslichkeit: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• SMILES String: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• InChIKey: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Beschreibung

Allgemeine Beschreibung

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Anwendung

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem./physiol. Wirkung

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Vorsicht

Hygroscopic; light sensitive.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H336,H361fd,H373
• P-Sätze: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Gefahreneinstufungen: Repr. 2 - STOT RE 2 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves