Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

View All Documentation

P4484

Sigma-Aldrich

Purvalanol A

≥98% (HPLC), powder

Synonym(e):

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C19H25ClN6O
CAS-Nummer:
212844-53-6
Molekulargewicht:
388.89
MDL-Nummer:
MFCD02179211
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24898543
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

methylene chloride: 50 mg/mL

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChIKey

PMXCMJLOPOFPBT-HNNXBMFYSA-N

Biochem./physiol. Wirkung

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Anthraquinones?Advances in Research and Application: 2012 Edition, 4-4 (2012)
Ling Yin et al.
Cell death & disease, 10(6), 385-385 (2019-05-18)
SE translocation (SET), an inhibitor of protein phosphatase 2A (PP2A), plays important roles in mitosis and possesses oncogenic activity in several types of cancer. However, little is known regarding its regulation. Here we reveal a novel phosphorylation site of SET
Lucía García-Gutiérrez et al.
Scientific reports, 9(1), 18693-18693 (2019-12-12)
Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27. The Myc-p27
Andrey Kan et al.
PloS one, 11(1), e0146227-e0146227 (2016-01-08)
Adaptive immune responses are complex dynamic processes whereby B and T cells undergo division and differentiation triggered by pathogenic stimuli. Deregulation of the response can lead to severe consequences for the host organism ranging from immune deficiencies to autoimmunity. Tracking
Chuangyu Wen et al.
Cancer letters, 383(2), 295-308 (2016-10-25)
5-fluorouracil (5-FU)-based chemotherapy is the main chemotherapeutic approach for colorectal cancer (CRC) treatment. Because chemoresistance occurs frequently and significantly limits CRC therapies, a novel agent is needed. Pseudolaric acid B (PAB), a small molecule derived from the Chinese medicinal herb
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.