P3075

Phenylarsin-Oxid

≥97%, powder

• Synonym(e): Arzen, Oxophenylarsin, PAO
• Empirische Formel (Hill-System): C₆H₅AsO
• CAS-Nummer: 637-03-6
• Molekulargewicht: 168.02
• Beilstein: 2935227
• EG-Nummer: 211-275-3
• MDL-Nummer: MFCD00001990
• UNSPSC-Code: 12352119
• PubChem Substanz-ID: 24898387
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥97%
• Form: powder
• Farbe: white to off-white
• mp (Schmelzpunkt): 145-148 °C
• Löslichkeit: DMSO: 50 mg/mL
• SMILES String: O=[As]c1ccccc1
• InChI: 1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
• InChIKey: BQVCCPGCDUSGOE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Anwendung

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem./physiol. Wirkung

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Leistungsmerkmale und Vorteile

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301 + H331,H410
• P-Sätze: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable