P0021

Pantoprazole sodium hydrate

≥98% (HPLC)

• Synonym(e): Pantozol Hydrat, Protonix Hydrat
• Empirische Formel (Hill-System): C₁₆H₁₄F₂N₃O₄S · Na · xH₂O
• CAS-Nummer: 718635-09-7
• Molekulargewicht: 405.35 (anhydrous basis)
• UNSPSC-Code: 12352203
• PubChem Substanz-ID: 329819976
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Farbe: white to off-white
• Löslichkeit: H₂O: ≥20 mg/mL
• Ersteller: Novartis
• Lagertemp.: −20°C
• SMILES String: O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
• InChI: 1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
• InChIKey: CGJRLPRCWSHOFU-UHFFFAOYSA-N
• Angaben zum Gen: human ... ATP4A(495) , ATP4B(496)

Beschreibung

Anwendung

Pantoprazole sodium hydrate has been used:

• as a standard in high-performance liquid chromatography (HPLC){58
• as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
• to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Biochem./physiol. Wirkung

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole is a gastric proton pump inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable