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N1537
NU7026
≥98% (HPLC), solid
Synonym(e):
2-(Morpholin-4-yl)-benzo[h]chromen-4-one
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About This Item
Empirische Formel (Hill-System):
C17H15NO3
CAS-Nummer:
Molekulargewicht:
281.31
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Qualitätsniveau
Assay
≥98% (HPLC)
Form
solid
Farbe
tan
Löslichkeit
DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble
Versandbedingung
wet ice
Lagertemp.
2-8°C
SMILES String
O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
InChI
1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChIKey
KKTZALUTXUZPSN-UHFFFAOYSA-N
Anwendung
NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).
Biochem./physiol. Wirkung
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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