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MSAB001

Sigma-Aldrich

SILu™Rich Anti-IL6 MAb, biotin conjugated

clone IL6-4G1, purified from hybridoma cell culture

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

mouse

Qualitätsniveau

200

Konjugat

biotin conjugate

Antikörperform

purified from hybridoma cell culture

Antikörper-Produkttyp

primary antibodies

Klon

IL6-4G1, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Konzentration

~1.0 mg/mL

Methode(n)

immunoblotting: suitable
immunoprecipitation (IP): 1-2 μg/test using concentrated supernatant of human osteosarcoma MG-63 cells induced with IL 1β

Isotyp

IgG1

UniProt-Hinterlegungsnummer

P05231

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... IL6(3569)

Immunogen

Recombinant IL6

Physikalische Form

Solution in 0.01 M phosphate buffered saline pH 7.4 containing 15 mM sodium azide

Rechtliche Hinweise

SILu is a trademark of Sigma-Aldrich Co. LLC

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Tove Boström et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1021, 3-13 (2015-11-14)
For protein analysis of biological samples, two major strategies are used today; mass spectrometry (MS) and antibody-based methods. Each strategy offers advantages and drawbacks. However, combining the two using an immunoenrichment step with MS analysis brings together the benefits of
Ailan Guo et al.
Molecular & cellular proteomics : MCP, 13(1), 372-387 (2013-10-17)
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and signal transduction. Lysine methylation is best known to
Regine M Schoenherr et al.
Proteomics, 16(15-16), 2141-2145 (2016-04-21)
Immunoaffinity enrichment of peptides coupled to multiple reaction monitoring-mass spectrometry (immuno-MRM) enables highly specific, sensitive, and precise quantification of peptides and post-translational modifications. Major obstacles to developing a large number of immuno-MRM assays are poor availability of monoclonal antibodies (mAbs)
L M Biasucci et al.
Circulation, 94(5), 874-877 (1996-09-01)
Elevated plasma levels of C-reactive protein have been found in the majority of patients with unstable angina. The evidence of elevated levels of acute-phase proteins in unstable angina is in line with a growing body of evidence that suggests that
Peter M Voorhees et al.
British journal of haematology, 161(3), 357-366 (2013-02-26)
Interleukin-6 (IL6) plays a central role in multiple myeloma pathogenesis and confers resistance to corticosteroid-induced apoptosis. We therefore evaluated the efficacy and safety of siltuximab, an anti-IL6 monoclonal antibody, alone and in combination with dexamethasone, for patients with relapsed or
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