MAK157
Renin Assay Kit
sufficient for 100 fluorometric tests
Synonym(e):
Renin Enzyme Detection Kit
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Alle Fotos(2)
About This Item
UNSPSC-Code:
12161503
NACRES:
NA.84
Empfohlene Produkte
Verwendung
sufficient for 100 fluorometric tests
Nachweisverfahren
fluorometric
Relevante Krankheit(en)
cardiovascular diseases
Lagertemp.
−20°C
Angaben zum Gen
human ... REN(5972)
rat ... REN(24715)
Verwandte Kategorien
Allgemeine Beschreibung
Renin, also known as angiotensinogenase, is an aspartyl protease that cleaves angiotensinogen to form angiotensin I, the initial and rate-limiting step of the renin-angiotensin system (RAS). This system plays a critical role in the regulation of blood pressure and fluid balance. Increased renin activity can result in hypertension due to increased vasoconstriction and fluid retention. Inhibitors of renin can be used as a treatment for hypertension.
Anwendung
Renin Assay Kit has been used to determine the activity of renin.
Eignung
The Renin Assay Kit provides a convenient and simple method for screening renin activity in a variety of samples or for screening renin inhibitors.
Prinzip
Renin activity is determined using a proprietary fluorescence resonance energy transfer (FRET) peptide containing a fluorescence quencher. Cleavage of the peptide by renin results in the production of a fluorescent product (λex = 540/λem = 590 nm). This assay is ~50-fold more sensitive than the EDANS/DABCYL-based assay.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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