M0689

Myelin Basic Protein Antigen from human brain

≥95% (SDS-PAGE)

• Synonym(e): Myelin Antigen, Myelin Basic Protein
• MDL-Nummer: MFCD03457654
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human brain
• Qualitätsniveau: 200
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Methode(n): ELISA: suitable
• UniProt-Hinterlegungsnummer: P02686
• Lagertemp.: −20°C
• Angaben zum Gen: human ... MBP(4155)

Beschreibung

Allgemeine Beschreibung

Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).

Anwendung

Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.

Biochem./physiol. Wirkung

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.

Determined using polyclonal and monoclonal antibodies against MBP.

Physikalische Form

Lyophilized from 10mM HCl.

Sonstige Hinweise

Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves