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Key Documents

M0418

Sigma-Aldrich

Melanin

BioReagent, Synthetic, suitable for cell culture

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About This Item

CAS-Nummer:
8049-97-6
EG-Nummer:
232-473-6
MDL-Nummer:
MFCD00131581
UNSPSC-Code:
12352209
NACRES:
NA.75

Biologische Quelle

synthetic

Produktlinie

BioReagent

Assay

≥97% (TLC)

Form

powder

Methode(n)

cell culture | mammalian: suitable

Löslichkeit

1 N NH4OH: 20 mg/mL

Lagertemp.

−20°C

InChI

1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3

InChIKey

XUMBMVFBXHLACL-UHFFFAOYSA-N

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Allgemeine Beschreibung

Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.

Anwendung

Melanin has been used:
  • to incubate normal human keratinocytes for Masson-Fontana staining
  • as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
  • as an absorber to mimic human skin or melanocytic nevi and melanoma

Biochem./physiol. Wirkung

Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.

Angaben zur Herstellung

Prepared by oxidation of tyrosine with hydrogen peroxide.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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PloS one, 7(1), e29493-e29493 (2012-01-14)
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A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship analysis indicated that 4-substituted amino groups with a tertiary amine side chain, such as chloroquine, were

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