M0194

Anti-Muscarinic Acetylcholine Receptor (M₃) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Muscarinic Acetylcholine Receptor M3 Antibody, Muscarinic Acetylcholine Receptor M3 Antibody - Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit
• MDL-Nummer: MFCD06798471
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: mouse, rat, human
• Methode(n): western blot: 1:200 using rat brain lysate
• UniProt-Hinterlegungsnummer: P20309
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CHRM3(1131) ; mouse ... Chrm3(12671) ; rat ... Chrm3(24260)

Beschreibung

Allgemeine Beschreibung

Cholinergic receptor muscarinic 3 (CHRM3) gene is located on the human chromosome at 1q43 and encodes for the M3 subtype of muscarinic acetylcholine (ACh) receptors. Muscarinic receptor 3 (M3R) is one of the five muscarinic receptors (M1R-M5R). It is a member of the class A family of G-protein coupled receptors (GPCRs). M3R is localized to the salivary glands, lachrymal glands, trachea and bronchi.

Spezifität

Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody recognizes rat, human, mouse Muscarinic Acetylcholine Receptor (M3).

Immunogen

synthetic peptide corresponding to amino acid residues 461-479 of the third intracellular loop of rat muscarinic acetylcholine receptor M₃. This sequence is identical in human, mouse, pig, and bovine.

Anwendung

Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody is used to tag muscarinic acetylcholine receptor (M3) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of muscarinic acetylcholine receptor (M3) in information processing and plastic changes in CNS function.

Biochem./physiol. Wirkung

Muscarinic receptor 3 (M3R) is involved in the contraction of the detrusor muscle. It is also involved in the secretion of saliva and bladder contraction. It participates in several pathological processes of lung disease, such as chronic obstructive pulmonary disease (COPD). Mutations in the CHRM3 gene is associated with congenital bladder malformations related to prune-belly-like syndrome (PBS).

Physikalische Form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H302 + H332,H311,H412
• P-Sätze: P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable