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Sigma-Aldrich

α-Ketoglutarsäure Natriumsalz

BioUltra

Synonym(e):

2-Oxo-glutarsäure, 2-Oxo-glutarsäure Natriumsalz, 2-Oxopentandisäure Mononatriumsalz

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About This Item

Lineare Formel:
HOOCCH2CH2COCOONa
CAS-Nummer:
22202-68-2
Molekulargewicht:
168.08
Beilstein:
4597521
EG-Nummer:
244-836-6
MDL-Nummer:
MFCD00064196
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24896216
NACRES:
NA.32

Produktlinie

BioUltra

Qualitätsniveau

200

Assay

≥98% (perchloric acid titration)

Form

powder

Verunreinigungen

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

Löslichkeit

H2O: 0.5 M, clear, colorless

Anionenspuren

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

Kationenspuren

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

Lagertemp.

2-8°C

SMILES String

[Na+].OC(=O)CCC(=O)C([O-])=O

InChI

1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);/q;+1/p-1

InChIKey

MOTOGHHLNTXPTI-UHFFFAOYSA-M

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Anwendung

α-Ketoglutaric acid sodium salt has been used in the human kynurenine amino transferase II (KAT II) inhibition spectra assay.

Biochem./physiol. Wirkung

α-Ketoglutaric acid is a key intermediate in the TCA Cycle. It also plays an important role in preventing nitrogen overload by combining with nitrogen released within the cell.
α-Ketoglutaric acid is the precursor for L-glutamic acid.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Amino Acids in Therapy: A Guide to the Therapeutic Application of Protein Constituents, 34-34 (1985)
Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions
Tuttle JB, et al.
ACS Medicinal Chemistry Letters, 4(1), 37-40 (2012)
Michael E Jung et al.
The Journal of organic chemistry, 77(23), 11002-11005 (2012-11-21)
Oxidative cleavage of cycloalkene-1-carboxylates, made from the corresponding carboxylic acids, and subsequent oxidation of the resulting ketoaldehyde afforded the important 1-monoesters of 2-ketoalkanedioic acids. Thus ozonolysis of octyl cyclobutene-1-carboxylate followed by sodium chlorite oxidation afforded the 1-monooctyl 2-ketoglutarate. This is
Vivian R Moure et al.
Journal of bacteriology, 195(2), 279-286 (2012-11-13)
Fe protein (dinitrogenase reductase) activity is reversibly inactivated by dinitrogenase reductase ADP-ribosyltransferase (DraT) in response to an increase in the ammonium concentration or a decrease in cellular energy in Azospirillum brasilense, Rhodospirillum rubrum, and Rhodobacter capsulatus. The ADP-ribosyl is removed
Kenji Manabe et al.
Microbial cell factories, 12, 18-18 (2013-02-20)
The Bacillus subtilis genome-reduced strain MGB874 exhibits enhanced production of exogenous extracellular enzymes under batch fermentation conditions. We predicted that deletion of the gene for RocG, a bi-functional protein that acts as a glutamate dehydrogenase and an indirect repressor of
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Protokolle

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Chromatograms

application for HPLC

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