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Key Documents

JN0007

Sigma-Aldrich

Sabeluzole

≥98% (HPLC)

Synonym(e):

(RS)-1-(4-(Benzo[d]thiazol-2-yl(methyl)amino)piperidin-1-yl)-3-(4-fluorophenoxy)propan-2-ol, (RS)-1-[4-[1,3-Benzothiazol-2-yl(methyl)amino]-1-piperidyl]-3-(4-fluorophenoxy)propan-2-ol, (RS)-4-(2-Benzothiazolylmethylamino)-a-[(4-fluorophenoxy)methyl]-1-piperidineethanol, Arbetuzole, R 58 735, R 58,735, R 58735, R-58,735, R058735, R58 735, R58735

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About This Item

Empirische Formel (Hill-System):
C22H26FN3O2S
CAS-Nummer:
104383-17-7
Molekulargewicht:
415.52
MDL-Nummer:
MFCD00865935
UNSPSC-Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear

Lagertemp.

room temp

InChI

1S/C22H26FN3O2S/c1-25(22-24-20-4-2-3-5-21(20)29-22)17-10-12-26(13-11-17)14-18(27)15-28-19-8-6-16(23)7-9-19/h2-9,17-18,27H,10-15H2,1H3

InChIKey

IGMKTIJBFUMVIN-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Sabeluzole is a benzothiazole derivative that exerts neuroprotective and cognition-enhancing (nootropic) efficacy by preventing NMDA- and glutamate-induced neurotoxicity.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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P J Pauwels et al.
Synapse (New York, N.Y.), 12(4), 271-280 (1992-12-01)
The neuroprotective properties of the cognitive enhancer sabeluzole were investigated in rat brain neuronal cultures derived from the hippocampal formation of 17-day-old rat embryos. Measurement of the neuronal cytoskeletal microtubule-associated protein, MAP2, was used to assess survival of neurons after
H Geerts et al.
Neurobiology of aging, 17(4), 573-581 (1996-07-01)
There is growing evidence that cytoskeletal instability of neuronal cells is an important step towards tangle formation and subsequent functional disconnection in the AD brain. Sabeluzole, a new drug in clinical trials for Alzheimer's disease (AD), has been shown to
D Uberti et al.
Synapse (New York, N.Y.), 26(2), 95-103 (1997-06-01)
Sabeluzole was described to have antiischemic, antiepileptic, and cognitive-enhancing properties, and is currently under development for Alzheimer's disease. Recently, it was reported that repeated treatments with sabeluzole protect cultured rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity. We evaluated the
H W Boddeke et al.
Basic research in cardiology, 84(5), 489-498 (1989-09-01)
In the guinea pig heart-lung preparation, the protective effects of nifedipine and R 58735 on cardiovascular alterations following mild (35 min) and severe (60 min) ischemia and reperfusion (30 min) were studied. Nifedipine and R 58735 were equi-protective against the
M De Ryck et al.
Stroke, 21(11 Suppl), III158-III163 (1990-11-01)
Unilateral photochemical infarcts were produced in the hind limb sensorimotor neocortex of 243 rats by intravenous injection of the fluorescein derivative Rose Bengal and focal illumination of the intact skull surface. Facial contact stimuli governed the degree and recovery rate
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