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Merck

I6760

Sigma-Aldrich

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse

clone HP-6017, ascites fluid

Synonym(e):

Monoclonal Anti-Human IgG (Fc specific), Anti Human Igg Monoclonal Antibody, Anti-Human Fc Monoclonal Antibody, Anti-Human Fc Monoclonal Antibody - Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse, Mouse Anti-Human Igg

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

ascites fluid

Antikörper-Produkttyp

secondary antibodies

Klon

HP-6017, monoclonal

Enthält

15 mM sodium azide

Speziesreaktivität

rabbit, sheep, horse (IgG), goat, human

Methode(n)

indirect ELISA: 1:3,000

Isotyp

IgG2a

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

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Allgemeine Beschreibung

Monoclonal Anti-Human IgG (mouse IgG2a isotype) is derived from the hybridoma1 produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins (Igs) belongs immunoglobulin super-family and have two heavy (H) and two light (L) chain, held together by disulphide linkages. The four classes of IgG can be IgG1, IgG2, IgG3 and IgG4. Each light chain comprises one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region.

Spezifität

The antibody is specific for the Fc portion of human IgG and recognizes an epitope common to all human IgG subclasses. This antibody was adopted as an Fc specific reagent in the IUIS/WHO study.

Anwendung

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • imprint immunofixation (IIF)
  • immunofluorometric assay (IFMA)
  • hemagglutination (HA)
  • hemagglutination inhibition (HAI)
  • particle counting immunoassay(PACIA)

Biochem./physiol. Wirkung

Although the antibody site is located in the terminal end of human IgG (part of the Fab fragment), the Fc portion has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess a "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of human IgG.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
Vossenaar ER, et al.
Arthritis Research & Therapy, 6(2), R142-R142 (2004)
Ratio of serum IgG3 to total IgG concentration and goiter size are independent factors in intractability of Graves' disease
Santoh T, et al.
Endocrine Journal, 0711080013-0711080013 (2007)
Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice
Lo M, et al.
The Journal of Biological Chemistry, 292(9), 3900-3908 (2017)
Structure and function of immunoglobulins
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125, S41-S52 (2010)
S Langy et al.
Infection and immunity, 66(6), 2854-2858 (1998-05-29)
The full-length cDNA sequence encoding Brugia malayi L3 paramyosin has been isolated by immunoscreening a cDNA library with a mouse antiserum raised against Wuchereria bancrofti L3 infective larvae. A recombinant truncated form of paramyosin was expressed as a glutathione S-transferase

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