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I5273

Sigma-Aldrich

Interleukin-5 human

recombinant, expressed in baculovirus infected Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder, suitable for cell culture

Synonym(e):

IL-5

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About This Item

MDL-Nummer:
MFCD00163946
UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in baculovirus infected Sf21 cells

Assay

≥97% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

0.1-0.5 ng/mL EC50

Mol-Gew.

32-34 kDa

Verpackung

pkg of 5 μg

Konzentration

0.5-10 ng/mL

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P05113

Lagertemp.

−20°C

Angaben zum Gen

human ... IL5(3567)

Verwandte Kategorien

Biochem./physiol. Wirkung

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.
Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Angela Silveira et al.
Atherosclerosis, 239(1), 125-130 (2015-01-15)
Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma
Takehito Kobayashi et al.
Allergology international : official journal of the Japanese Society of Allergology, 64 Suppl, S30-S36 (2015-09-08)
Eosinophils recognize various stimuli, such as cytokines, chemokines, immunoglobulins, complement, and external pathogens, resulting in their accumulation in mucosal tissues and the progression of inflammation. Eosinophils are also involved in innate Th2-type immune responses mediated through endogenous danger signals, including
Mandy E Burnham et al.
PloS one, 9(8), e103122-e103122 (2014-08-15)
Eosinophils function contributes to human allergic and autoimmune diseases, many of which currently lack curative treatment. Development of more effective treatments for eosinophil-related diseases requires expanded understanding of eosinophil signaling and biology. Cell signaling requires integration of extracellular signals with
Ma Paz Zafra et al.
International journal of molecular sciences, 16(3), 5434-5451 (2015-03-13)
Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high

Artikel

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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