I5159

Imiquimod

≥98% (HPLC), solid, caspase 3 activator

• Synonym(e): 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
• Empirische Formel (Hill-System): C₁₄H₁₆N₄
• CAS-Nummer: 99011-02-6
• Molekulargewicht: 240.30
• MDL-Nummer: MFCD00866946
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724516
• NACRES: NA.77

Eigenschaften

• product name: Imiquimod, ≥98% (HPLC), solid
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: H₂O: <2 mg/mL; DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
• SMILES String: CC(C)Cn1cnc2c(N)nc3ccccc3c12
• InChI: 1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
• InChIKey: DOUYETYNHWVLEO-UHFFFAOYSA-N
• Angaben zum Gen: human ... TLR7(51284)

Beschreibung

Allgemeine Beschreibung

Imiquimod is a toll-like receptor (TLR)-7/8 agonist.

Anwendung

Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies. It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.

Biochem./physiol. Wirkung

Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Leistungsmerkmale und Vorteile

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319
• P-Sätze: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges