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I3400

Sigma-Aldrich

Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(e):

CXCL10, IP-10

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About This Item

MDL-Nummer:
MFCD00241912
UNSPSC-Code:
51111800
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Assay

≥97% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

0.015-0.075 μg/mL ED50 (chemoattract mouse BaF3 cells transfected with hCXCR3)
0.03-0.18 μg/mL ED50 (chemoattract T-Lymphocytes)

Mol-Gew.

8.7 kDa

Verpackung

pkg of 10 μg

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P01579

Lagertemp.

−20°C

Angaben zum Gen

human ... CXCL10(3627)

Allgemeine Beschreibung

The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

Biochem./physiol. Wirkung

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.
IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

Hinweis zur Analyse

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Daniel Kotrych et al.
Rheumatology international, 35(8), 1319-1323 (2015-02-24)
Chemokines (CXCL) and their receptors play important roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the CXCL9 (rs3733236 G>A) and CXCL10 (rs8878 A>G) genes and RA. We
Chia-Chu Chang et al.
Scientific reports, 5, 10096-10096 (2015-05-12)
Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating

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