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I1646

Sigma-Aldrich

Interleukin-3 human

IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

hIL-3, IL-3

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About This Item

MDL-Nummer:
MFCD00147276
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in E. coli

Assay

≥97% (HPLC and SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

≤1.0 ng/mL ED50/EC50

Qualität

endotoxin tested

Mol-Gew.

15 kDa

Verpackung

pkg of 10 and 50 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤0.1 EU/μg

UniProt-Hinterlegungsnummer

P08700

Lagertemp.

−20°C

Angaben zum Gen

human ... IL3(3562)

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Verwandte Kategorien

Biochem./physiol. Wirkung

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Physikalische Form

Lyophilized with no additives. Sterile filtered through a 0.2 μm filter.

Hinweis zur Analyse

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Bingrui Wang et al.
Cell discovery, 8(1), 41-41 (2022-05-10)
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production
Jinhua Liu et al.
Nature communications, 9(1), 4386-4386 (2018-10-24)
In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular processes, their involvement in heme-dependent
Kerstin Kapp et al.
Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist
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Artikel

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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