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I0909

Sigma-Aldrich

6-Iodonordihydrocapsaicin

≥98% (HPLC), solid

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About This Item

Empirische Formel (Hill-System):
C17H26INO3
CAS-Nummer:
859171-97-4
Molekulargewicht:
419.30
MDL-Nummer:
MFCD09878233
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24895913
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

protect from light

Farbe

white

Löslichkeit

DMSO: ~44 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

CCCCCCCCC(=O)NCc1cc(OC)c(O)cc1I

InChI

1S/C17H26INO3/c1-3-4-5-6-7-8-9-17(21)19-12-13-10-16(22-2)15(20)11-14(13)18/h10-11,20H,3-9,12H2,1-2H3,(H,19,21)

InChIKey

AAORACFZMYMFCG-UHFFFAOYSA-N

Angaben zum Gen

human ... TRPV1(7442)

Biochem./physiol. Wirkung

TRPV1 (V1) vanilloid receptor antagonist.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Giovanni Appendino et al.
British journal of pharmacology, 139(8), 1417-1424 (2003-08-19)
1. The C-5 halogenation of the vanillyl moiety of resiniferatoxin, an ultrapotent agonist of vanilloid TRPV1 receptors, results in a potent antagonist for these receptors. Here, we have synthesized a series of halogenated derivatives of 'synthetic capsaicin' (nonanoyl vanillamide=nordihydrocapsaicin) differing
Yuriko Oi-Kano et al.
The Journal of nutritional biochemistry, 40, 209-218 (2016-12-13)
Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is a major phenolic compound in extra virgin olive oil and the absorbed form of oleuropein. We aimed to determine the mechanism underlying the nutritional effects of oleuropein and
Daniela L Uliana et al.
Journal of psychopharmacology (Oxford, England), 34(9), 1043-1055 (2020-07-09)
Blockade of cannabinoid CB1 or vanilloid TRPV1 receptors in the ventromedial prefrontal cortex of rats respectively increases or decreases the conditioned emotional response during re-exposure to a context previously paired with footshocks. Although these mechanisms are unknown, they may involve
Manoela V Fogaça et al.
Pharmacology, biochemistry, and behavior, 129, 7-13 (2014-12-03)
Hemopressin (PVNFKFLSH; HP) is an orally active peptide derived from rat hemoglobin α-chain that could act as an inverse agonist at cannabinoid type 1 receptors (CB1). Here, we aim to investigate possible behavioral effects of HP in male Wistar rats
Azucena Perez-Burgos et al.
The Journal of physiology, 593(17), 3943-3957 (2015-06-19)
Certain probiotic bacteria have been shown to reduce distension-dependent gut pain, but the mechanisms involved remain obscure. Live luminal Lactobacillus reuteri (DSM 17938) and its conditioned medium dose dependently reduced jejunal spinal nerve firing evoked by distension or capsaicin, and

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