H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

≥98% (HPLC), solid

• Synonym(e): (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
• Empirische Formel (Hill-System): C₁₆H₂₅NO · HBr
• CAS-Nummer: 78095-19-9
• Molekulargewicht: 328.29
• MDL-Nummer: MFCD00153810
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278480
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Optische Aktivität: [α]25/D +68.2°, c = 1 in methanol(lit.)
• Lagerbedingungen: desiccated; protect from light
• Farbe: white to off-white
• Löslichkeit: H₂O: >10 mg/mL at ±60 °C (with sonication)
• SMILES String: Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
• InChI: 1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1
• InChIKey: BATPBOZTBNNDLN-PFEQFJNWSA-N
• Angaben zum Gen: human ... HTR1A(3350)

Beschreibung

Anwendung

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:

• in mice to test the activity of the serotonin receptor
• to test its effect on zebrafish melanocyte migration and survival
• to stimulate hippocampal neurons

Biochem./physiol. Wirkung

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT_1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)