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GW22829

Anti-PSMC5 antibody produced in chicken

Name: Anti-PSMC5 antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC-Code:

12352203

NACRES:

NA.41

Konjugat:

unconjugated

application:

Klon:

polyclonal

Speziesreaktivität:

human, rat

citations:

Methode(n):

western blot: suitable

Biologische Quelle

chicken

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human, rat

Hersteller/Markenname

Genway 15-288-22829

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_002796.4

UniProt-Hinterlegungsnummer

P62195

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PSMC5(5705)

Allgemeine Beschreibung

PSMC5 (proteasome 26S subunit, ATPase, 5) is a regulatory subunit of the 26S proteasome belonging to the family of putative ATPases. It has structural homology with yeast Sug1p gene.

Immunogen

Immunogen Sequence: GI # 24497435, sequence 2-160

Recombinant proteasome 26S ATPase subunit 5

Anwendung

Anti-PSMC5 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

26S protease regulatory subunit 8 is an enzyme encoded by the PSMC5 gene in humans and is important for the transcription of MHC II molecules. It has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. PSMC5 acts as a key regulator of collagen contraction in primary human lung fibroblasts (a functional characteristic of myofibroblasts) and is a critical step in the process of fibrosis.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

049K1869

029K1941

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Die Dokumentenbibliothek aufrufen

TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation.

Michael F Nyp et al.

Respiratory research, 15, 19-19 (2014-02-18)

Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p.

K Akiyama et al.

FEBS letters, 363(1-2), 151-156 (1995-04-17)

The nucleotide sequence of a cDNA that encodes a new regulatory subunit, named p45, of the 26S proteasome of human hepatoblastoma HepG2 cells has been determined. The polypeptide predicted from the open reading frame consists of 406 amino acid residues

Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.

Yaritza Inostroza-Nieves et al.

Immunology letters, 147(1-2), 67-74 (2012-07-10)

The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of

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