GW22681
Anti-MUC1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Empfohlene Produkte
Biologische Quelle
chicken
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Speziesreaktivität
human, mouse, rat
Hersteller/Markenname
Genway 15-288-22681
Methode(n)
immunohistochemistry: suitable
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... MUC1(4582)
Allgemeine Beschreibung
Mucin 1 (MUC1) is a O-glycosylated, membrane bound, transmembrane glycoprotein belonging to the mucin (MUC) gene family. It is expressed on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It consists of an N-terminal extracellular domain consisting of variable number tandem repeats (MUC1-TR) of 20 amino acids (aa) and a C-terminal domain which includes a 53aa extracellular region, a transmembrane domain (TM) and a 72aa cytoplasmic tail (MUC1CT).
Anwendung
Anti-MUC1 antibody produced in chicken is suitbale for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem./physiol. Wirkung
Mucin 1, cell surface associated (MUC1), plays an important role in the cell signaling during cancer progression. It carries tumor-associated epitopes and is aberrantly expressed in tumors. MUC1 plays a crucial role in the development, progression of breast cancer and could promote the invasion ability of breast cancer cells. Mutation in the gene may result in progressive chronic kidney failure with a bland urinary sediment.
Physikalische Form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Beschreibung
Preisangaben
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Anthony J Bleyer et al.
Clinical journal of the American Society of Nephrology : CJASN, 9(3), 527-535 (2014-02-11)
The genetic cause of medullary cystic kidney disease type 1 was recently identified as a cytosine insertion in the variable number of tandem repeat region of MUC1 encoding mucoprotein-1 (MUC1), a protein that is present in skin, breast, and lung
S J Gendler et al.
The Journal of biological chemistry, 265(25), 15286-15293 (1990-09-05)
Human mammary cells present on the cell surface a polymorphic epithelial mucin (PEM) which is developmentally regulated and aberrantly expressed in tumors. PEM carries tumor-associated epitopes recognized by the monoclonal antibodies HMFG-1, HMFG-2, and SM-3. Previously isolated partial cDNA clones
Yaron Niv et al.
World journal of gastroenterology, 20(40), 14913-14920 (2014-10-31)
To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori (H. pylori)-associated, non-steroidal inflammatory drug (NSAID)-associated and idiopathic-gastric ulcers. We studied a cohort of randomly selected patients with H. pylori (group 1, n =
Lili Zhang et al.
The Journal of pathology, 234(1), 60-73 (2014-05-20)
Cigarette smoke increases the risk of lung cancer by 20-fold and accounts for 87% of lung cancer deaths. In the normal airway, heavily O-glycosylated mucin-1 (MUC1) and adherens junctions (AJs) establish a structural barrier that protects the airway from infectious
M Sahraei et al.
Oncogene, 31(47), 4935-4945 (2012-01-24)
Pancreatic ductal adenocarcinoma (PDA) has one of the worst prognoses of all cancers. Mucin 1 (MUC1), a transmembrane mucin glycoprotein, is a key modulator of several signaling pathways that affect oncogenesis, motility and metastasis. Its expression is known to be
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