Alle Fotos(1)

Wichtige Dokumente

Gesamtdokumentation anzeigen

GW21469

Anti-PTPRF antibody produced in chicken

Name: Anti-PTPRF antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-Receptor-type tyrosine-protein phosphatase F

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

Alle Fotos(1)

About This Item

UNSPSC-Code:

12352203

NACRES:

NA.41

Biologische Quelle

chicken

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

rat, human, mouse

Hersteller/Markenname

Genway 15-288-21469

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_002831.1

UniProt-Hinterlegungsnummer

P10586

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PTPRF(5792)

Immunogen

Immunogen Sequence: GI # 4506311, sequence 1151-1225

Recombinant protein tyrosine phosphatase, receptor type, F isoform 1

Anwendung

Anti-PTPRF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Receptor-type tyrosine-protein phosphatase F is an enzyme encoded by the PTPRF gene in humans. It localizes to adherens junctions and may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling and the canonical Wnt pathway. PTPRF induction occurs by cell-cell contact during cell proliferation that activates ERK-dependent proliferation signaling to prevent cell hyperproliferation and tumor initiation. It acts as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin. PTPRF regulates cell proliferation, response to growth factors and cellular adhesion. Mutation in the gene is associated with breast cancer.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Homozygous truncating PTPRF mutation causes athelia.

Guntram Borck et al.

Human genetics, 133(8), 1041-1047 (2014-05-02)

Athelia is a very rare entity that is defined by the absence of the nipple-areola complex. It can affect either sex and is mostly part of syndromes including other congenital or ectodermal anomalies, such as limb-mammary syndrome, scalp-ear-nipple syndrome, or

Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.

Rabindranath Bera et al.

Hepatology (Baltimore, Md.), 59(6), 2238-2250 (2014-01-29)

It is unclear how proliferating cells elicit suppression on cell proliferation and how cancer cells evade this growth suppression. Using a loss-of-function screening of the human kinome and phosphatome to identify genes suppressing tumor initiation in human hepatocellular carcinoma (HCC)

Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.

T Yang et al.

Molecular carcinogenesis, 25(2), 139-149 (1999-06-12)

The findings that protein tyrosine phosphatases (PTPs) regulate cell proliferation, response to growth factors, and cellular adhesion and the discovery that mutations in PTP genes are associated with breast cancer suggest that altered expression of PTPs contributes to the breast

Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.

Ann Mander et al.

FEBS letters, 579(14), 3024-3028 (2005-05-18)

To test the role of the leukocyte common antigen-related protein tyrosine phosphatase (LAR) as a regulator of insulin receptor (IR) signalling, an siRNA probe against LAR was developed. Knock-down of LAR induced post-receptor insulin resistance with the insulin-induced activation of

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.