GW21011
Anti-β-2 Adrenergic Receptor antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(e):
Anti-β-2 adrenergic receptor, Anti-β-2 adrenoreceptor
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About This Item
Biologische Quelle
chicken
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Speziesreaktivität
human
Hersteller/Markenname
Genway 15-288-21011
Methode(n)
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... ADRB2(154)
Allgemeine Beschreibung
β-2 Adrenergic Receptor is a member of the seven-transmembrane-domain receptor family. The ADRB2 gene is mapped on the human chromosome at 5q32. β-2 Adrenergic Receptor is a seven-transmembrane protein that consists of α helices. The N-terminal is extracellular whereas the C-terminal is intracellular.
Immunogen
Immunogen Sequence: GI # 4501969, sequence 335-408
Recombinant adrenergic, β-2-, receptor, surface
Anwendung
Anti-β-2 Adrenergic Receptor antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem./physiol. Wirkung
The β-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is present within a cell membrane. It reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It may be a risk factor for chronic pain and its polymorphisms may influence labor pain. It contains a common non-synonymous single nucleotide polymorphism. Epinephrine activates ADRB2 impairing keratinocyte migration. β2-adrenoceptor pathway is essential for cardiovascular regulation.
Physikalische Form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analysenzertifikate (COA)
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U H Frey et al.
British journal of anaesthesia, 112(3), 477-484 (2013-12-25)
While the β2-adrenoceptor pathway is essential for cardiovascular regulation, the impact of ADRB2 gene variations on circulatory responses is unclear, possibly due to neural compensatory mechanisms. We tested the hypotheses that (i) sympathetic block by thoracic epidural anaesthesia (TEA) unmasks
Dennis W McGraw et al.
Proceedings of the American Thoracic Society, 2(4), 292-296 (2005-11-04)
It is now clear that the beta2-adrenergic receptor continuously oscillates between various conformations in the basal state, and that agonists act to stabilize one or more conformations. It is conceivable that synthetic agonists might be engineered to preferentially confine the
R A Hall et al.
Nature, 392(6676), 626-630 (1998-04-29)
Stimulation of beta2-adrenergic receptors on the cell surface by adrenaline or noradrenaline leads to alterations in the metabolism, excitability, differentiation and growth of many cell types. These effects have traditionally been thought to be mediated exclusively by receptor activation of
Victor E Ortega et al.
The Lancet. Respiratory medicine, 2(3), 204-213 (2014-03-14)
Severe adverse life-threatening events associated with longacting β agonist (LABA) use have caused the US Food and Drug Administration (FDA) to review the safety of these drugs, resulting in a boxed warning and a mandatory safety study in 46 800 patients
Abdullah S Terkawi et al.
Anesthesiology, 121(1), 140-148 (2014-04-10)
Variability in labor pain has been associated with demographic, clinical, and psychological factors. Polymorphisms of the β2-adrenergic receptor gene (ADRB2) influence sensitivity to experimental pain in humans and are a risk factor for chronic pain. The authors hypothesized that polymorphisms
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