G9893

Gliotoxin

from Gliocladium fimbriatum, ≥98% (HPLC), powder, immunomodulating agent

• Synonym(e): Aspergillin
• Empirische Formel (Hill-System): C₁₃H₁₄N₂O₄S₂
• CAS-Nummer: 67-99-2
• Molekulargewicht: 326.39
• Beilstein: 50675
• MDL-Nummer: MFCD00058534
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24895384
• NACRES: NA.77

Eigenschaften

• product name: Gliotoxin aus Gliocladium fimbriatum,
• Qualitätsniveau: 200
• Wirkungsspektrum von Antibiotika: viruses
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
• InChI: 1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
• InChIKey: FIVPIPIDMRVLAY-RBJBARPLSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: epipolythiodioxopiperazine

Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.

Anwendung

Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.

Nicht-kompetitiver Hemmer der chymotrypsin-ähnlichen Aktivität des 20S Proteasoms in vitro.

Biochem./physiol. Wirkung

Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges