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G8546

Sigma-Aldrich

p38γ, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

ERK3, ERK6, MAPK12, PRKM12, SAPK3

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About This Item

UNSPSC-Code:
51111800
NACRES:
NA.32

Rekombinant

expressed in baculovirus infected Sf9 cells

Qualitätsniveau

200

Produktlinie

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

56-76 nmol/min·mg

Mol-Gew.

~71 kDa

UniProt-Hinterlegungsnummer

P53778

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... MAPK12(6300)

Allgemeine Beschreibung

p38γ, commonly known as MAPK12 (mitogen-activated protein kinase 12), is one of the four isoforms of the p38 MAPK family. This isoform shows predominant expression in skeletal muscle and is controlled by exercise.

Biochem./physiol. Wirkung

p38γ is a key protein of the MAPK (mitogen-activated protein kinase) pathway and is involved in cell differentiation, growth, cycle and apoptosis and inflammation. It is essential for normal localization of polo-like kinase 1 (Plk1) at the kinetochore. This protein facilitates mitotic cell viability and suppresses chromosomal instability. Studies suggest that this protein negatively controls the expression of GLUT4 (glucose transporter) and the uptake of glucose mediated by contraction in adult skeletal muscles.

Physikalische Form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Rechtliche Hinweise

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLBZ4978
SLBC0495V
SLBB6658V

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Die Dokumentenbibliothek aufrufen

Richard C Ho et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 286(2), R342-R349 (2003-11-01)
Skeletal muscle expresses at least three p38 MAPKs (alpha, beta, gamma). However, no studies have examined the potential regulation of glucose uptake by p38gamma, the isoform predominantly expressed in skeletal muscle and highly regulated by exercise. L6 myotubes were transfected
Anu Kukkonen-Macchi et al.
Journal of cell science, 124(Pt 2), 216-227 (2010-12-22)
The p38 mitogen-activated protein kinase (p38 MAPK) family, which is comprised of four protein isoforms, p38α, p38β, p38γ and p38δ, forms one of the key MAPK pathways. The p38 MAPKs are implicated in many cellular processes including inflammation, differentiation, cell
Z Li et al.
Biochemical and biophysical research communications, 228(2), 334-340 (1996-11-12)
We have identified a third member of the p38 group of MAP kinase termed p38 gamma. The cDNA for this MAP kinase encodes an 367 amino acid polypeptide that is slightly greater than 60% identical to p38 and p38 beta.

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