G117

Glipizid

solid

• Synonym(e): 1-Cyclohexyl-3-{4-[2-(5-methylpyrazin-2-carboxamido)-ethyl]-phenylsulfonyl}-harnstoff
• Empirische Formel (Hill-System): C₂₁H₂₇N₅O₄S
• CAS-Nummer: 29094-61-9
• Molekulargewicht: 445.54
• EG-Nummer: 249-427-6
• MDL-Nummer: MFCD00072159
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277839
• NACRES: NA.77

Eigenschaften

• Form: solid
• Farbe: white
• Löslichkeit: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES String: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChIKey: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• Angaben zum Gen: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

Beschreibung

Allgemeine Beschreibung

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Anwendung

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

Biochem./physiol. Wirkung

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)